Our Research

Neural Network Dysfunctions in Neuropsychiatric Disorders
Blood-Brain Barrier Dysfunctions in Neurodevelopmental Disorders


We are grateful to the funding agencies for supporting our research

Current funding:

R01 AG75000: 2022-2027

Losing specificity: the role of the locus coeruleus in age-related distractibility

R01 MH117429: 2019-2024

Genes, Neural Circuits, and Behavior

Completed funding:

R56 MH117429: 2018-2019

NARSAD Young Investigator Grant (Brain & Behavior Research Foundation): 2017-2019


Dr. Henry Yin, Duke University
Dr. Changwon Park, LSU
Dr. Yong-Hui Jiang, Yale University
Dr. Tae-Ho Lee, Virginia Tech
Dr. William Wetsel, Duke University
Dr. Soo Chan Lee, UTSA
Dr. Detlef Heck, UTHSC
Dr. Jianyang Du, UTHSC
Dr. Hyun Kim, Korea University
Dr. Jiyeon Kim, Yale University


Kim YE, Kim S, Kim IH (2022). Neural circuit-specific gene manipulation in mouse brain in vivo using split-Intein mediated split-Cre system. STAR Protocols. 2022. https://doi.org/10.1016/j.xpro.2022.101807

Kim S, Kim YE, Kim IH (2022). Simultaneous Analysis of Social Behaviors and Neural Responses in Mice using Round Social Arena System. STAR Protocols. 2022 Sep 24;3(4):101722. doi: 10.1016/j.xpro.2022.101722.

Kim S, Kim Y, Song I, Ujihara Y, Kim N, Jiang Y, Yin H, Lee T, Kim IH. Neural Circuit Pathology Driven by Shank3 Mutation Disrupts Social Behaviors. Cell Reports. 2022 Jun 7;39(10):110906. doi: 10.1016/j.celrep.2022.110906. This paper is a cover story for the issue. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00681-7

Courtland J, Bradshaw T, Waitt G, Soderblom E, Ho T, Rajab A, Vancini R, Huang T, Vitek O, Kim IH*, and Soderling S*. Genetic Disruption of WASHC4 Drives Endo-lysosomal Dysfunction and Cognitive-Movement Impairments in Mice and Humans. Elife. 2021 Mar 22;10. doi: 10.7554/eLife.61590. *Co-corresponding author.

Kim IH*, Kim N, Kim S, Toda K, Catavero CM, Courtland JL, Yin HH, Soderling SH. Dysregulation of the Synaptic Cytoskeleton in the PFC Drives Neural Circuit Pathology, Leading to Social Dysfunction. Cell Reports. 2020 Jul 28;32(4):107965. doi: 10.1016/j.celrep.2020.107965. *Co-corresponding author.

Kim N, Li HE, Hughes RN, Watson GDR, Gallegos D, West AE, Kim IH, Yin HH.. A striatal interneuron circuit for continuous target pursuit. Nature Communications. 2019 Jun 20;10(1):2715. doi: 10.1038/s41467-019-10716-w.

Kinoshita N, Huang AJY, McHugh TJ, Suzuki SC, Masai I, Kim IH, Soderling SH, Miyawaki A, Shimogori T. Genetically Encoded Fluorescent Indicator GRAPHIC Delineates Intercellular Connections. iScience. 2019 Apr 11;15:28-38. doi: 10.1016/j.isci.2019.04.013.

Choi HW, Suwanpradid J, Kim IH, Staats HF, Haniffa M, MacLeod AS, Abraham SN. Perivascular Dendritic Cells Elicit Anaphylaxis by Relaying Allergens to Mast Cells via Microvesicles. Science, 2018 Nov 9;362(6415). pii: eaao0666. doi: 10.1126/science.aao0666.

Chung L, Bey AL, Towers AJ, Cao X, Kim IH, Jiang Y, Lovastatin suppresses hyperexcitability and seizure in Angelman syndrome model. Neurobiology of Disease, 2017 Oct 30. S0969-9961(17)30242-5. doi:10.1016/j.nbd. 2017.10.016

Chung S*, Kim IH*, Lee D*, Park K, Kim JY, Lee YK, Kim EJ, Choi J, Son GH, Sun W, Shin K, Kim H. The role of inositol 1,4,5-trisphosphate 3-kinase A in regulating emotional behavior and amygdala function. Scientific Reports. 2016 Apr 7;6:23757. doi: 10.1038/srep23757. *Co-first author.

Rossi MA, Li HE, Lu D, Kim IH, Bartholomew RA, Gaidis E, Barter JW, Kim N, Cai MT, Soderling SH, Yin HH.. A GABAergic nigrotectal pathway for coordination of drinking behavior. Nature Neuroscience. 2016 Apr 4. doi: 10.1038/nn.4285.

Sing SK, Stogsdill JA, Pulimood NS, Dingsdale H, Kim YH, Pilaz LJ, Kim IH, Manhaes AC, Rodriguez-Junior WS, Pamukcu A, Enustun E, Ertuz Z, Scheiffele P, Soderling SH, Silver DS, Ji R-R, Medina AE, Eroglu C. Astrocytes assemble thalamocortical synapses by bridging neurexin1-alpha and neuroligin-1 via hevin. Cell. 2016 Jan 14;164(1-2):183-96. doi: 10.1016/j.cell.2015. 11.034.

Chung L, Wang X, Zhu L, Towers A, Kim IH, Jiang YH. Parental origin impairment of synaptic functions and behaviors in cytoplasmic FMRP interacting protein 1 (Cyfip1) deficiency mice. Brain Res. 2015 Oct 16. pii: S0006-8993(15)00752-0. doi: 10.1016/j.brainres.

Kim IH*, Rossi MA, Aryal DK, Racz B, Kim N, Uezu A, Wang F, Wetsel WC, Weinberg RJ, Yin H, Soderling SH. Spine Pruning Drives Antipsychotic-sensitive Locomotion via Circuit Control of Striatal Dopamine. Nature Neuroscience. 2015 May 4. doi: 10.1038/nn.4015. News and Views: Nature Neuroscience: http://www.nature.com/neuro/journal/v18/n6/full/nn.4029.html. Nature Reviews: http://www.nature.com/nrn/journal/v16/n7/full/nrn3980.html. Schizophrenia Forum: http://www.schizophreniaforum.org/new/detail.asp?id=2177 LA Times: http://www.latimes.com/science/sciencenow/la-sci-sn-schizophrenia-secrets-20150504-story.html *Co-corresponding author.

Risher WC, Patel S, Kim IH, Uezu A, Bhagat S, Wilton DK, Pilaz LJ, Singh Alvarado J, Calhan OY, Silver DL, Stevens B, Calakos N, Soderling SH, Eroglu C. Astrocytes refine cortical connectivity at dendritic spines. Elife. 2014 Dec 17;3. doi: 10.7554/eLife.04047

Kim IH, Wang H, Soderling HS, Yasuda R. Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall. Elife. 2014 Jul 8;3. doi: 10.7554/eLife.02839

Wetsel WC, Rodriguiz RM, Guillemot J, Rousselet E, Essalmani R, Kim IH, Bryant JC, Marcinkiewicz J, Desjardins R, Day R, Constam DB, Prat A, Seidah NG. Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice. PNAS. 2013 Oct 22;110(43):17362-7.

Kim IH, Racz B, Wang H, Burianek L, Weinberg R, Yasuda R, Wetsel WC, Soderling SH. Disruption of Arp2/3 Results in Asymmetric Structural Plasticity of Dendritic Spines and Progressive Synaptic and Behavioral Abnormalities. J. Neuroscience. 2013 Apr 3;33(14):6081-6092. This paper is a cover story of the issue. http://www.jneurosci.org/content/33/14.cover-expansion

Kim IH, Carlson BR, Heindel CC, Kim H, Soderling SH. Disruption of Wave Associated Rac-GAP (Wrp) Leads to Abnormal Adult Neural Progenitor Migration Associated with Hydrocephalus. J Biol Chem. 2012 Sep 24.

Lee D, Lee HW, Hong S, Choi BI, Kim HW, Han SB, Kim IH, Bae JY, Bae YC, Rhyu IJ, Sun W, Kim H. Inositol 1,4,5 trisphosphate 3-kinase A is a novel microtubule-associated protein: PKA-dependent phosphoregulation of microtubule binding affinity. J Biol Chem. 2012 Mar 2.

Carlson BR, Lloyd KE, Kruszewski A, Kim IH, Rodriguiz RM, Heindel C, Faytell M, Dudek SM, Wetsel WC, Soderling SH. WRP/srGAP3 Facilitates the Initiation of Spine Development by an Inverse F-BAR Domain and its Loss Impairs Long-Term Memory. J. Neuroscience. 2011 Feb 16;31(7):2447-60.

Pang MH, Kim NS, Kim IH, Kim H, Kim HT, Choi JS. Cholinergic transmission in the dorsal hippocampus modulates trace but not delay fear conditioning. Neurobiology of Learning and Memory. 2010 Sep;94(2):206-213.

Deng JV, Rodriguiz RM, Hutchinson AN, Kim IH, Wetsel WC, West AE. MeCP2 in the Nucleus Accumbens Contributes to Neural and Behavioral Responses to Psychostimulants. Nature Neuroscience. 2010 Aug 15.

Kim SC, Jo YS, Kim IH, Kim H, Choi JS. Lack of medial prefrontal cortex activation underlies the immediate extinction deficit. J. Neuroscience. 2010 Jan 20;30(3):832-7.

Kim IH, Park SK, Hong ST, Kim EJ, Jo YS, Park EH, Shin HS, Kim HT, Sun W, Soderling S.H., Kim H. Inositol 1,4,5-trisphosphate 3-kinase A Functions as a Scaffold for Synaptic Rac Signaling. J. Neuroscience. 2009 29(44):14039-49.

Jo YS, Park EH, Kim IH, Park SK, Kim H, Kim HT, Choi JS. The medial prefrontal cortex is involved in spatial memory retrieval under partial-cue conditions. J. Neuroscience. 2007 Dec 5;27(49):13567-78.

Kim IH, Park SK, Sun W, Kang Y, Kim HT, Kim H. Spatial learning enhances the expression of inositol 1,4,5-trisphosphate 3-kinase A in the hippocampal formation of rat. Brain Res Mol Brain Res. 2004 Apr 29;124(1):12-9.